Non-invasive urinary sediment double-immunostaining predicts BK polyomavirus associated-nephropathy in kidney transplant recipients
نویسندگان
چکیده
منابع مشابه
Neutralization Serotyping of BK Polyomavirus Infection in Kidney Transplant Recipients
BK polyomavirus (BKV or BKPyV) associated nephropathy affects up to 10% of kidney transplant recipients (KTRs). BKV isolates are categorized into four genotypes. It is currently unclear whether the four genotypes are also serotypes. To address this issue, we developed high-throughput serological assays based on antibody-mediated neutralization of BKV genotype I and IV reporter vectors (pseudovi...
متن کاملPre-transplant immune factors may be associated with BK polyomavirus reactivation in kidney transplant recipients
BK polyomavirus (BKPyV) reactivation in kidney transplant recipients can lead to allograft damage and loss. The elements of the adaptive immune system that are permissive of reactivation and responsible for viral control remain incompletely described. We performed a prospective study evaluating BKPyV-specific T-cell response, humoral response and overall T-cell phenotype beginning pre-transplan...
متن کاملBK Virus and Nephropathy in Kidney Transplant Recipients
Polyomavirus-associated nephropathy (PVAN) remains an important cause of allograft dysfunction and graft loss after kidney transplantation [1, 2]. Furthermore, up to 10% of renal transplant recipients show a viral reactivation that can lead to PVAN and delayed treatment results in high risk of graft loss (up to 80%) [3]. We read with interest the article published by Pakfetrat, et al [2], and w...
متن کاملUrinary exosomal viral microRNA as a marker of BK virus nephropathy in kidney transplant recipients
OBJECTIVE Bkv-miR-B1-5p, one of the microRNAs encoded by BK virus, was recently reported to be elevated in the blood among the patients with BK virus nephropathy (BKVN). Urinary exosome was suggested to be a possible source of biomarker for kidney diseases, but it was unknown whether it could contain viral microRNA as well as human microRNAs. The aim of this study was to evaluate whether urinar...
متن کاملInterplay of cellular and humoral immune responses against BK virus in kidney transplant recipients with polyomavirus nephropathy.
Reactivation of the polyomavirus BK (BKV) causes polyomavirus nephropathy (PVN) in kidney transplant (KTx) recipients and may lead to loss of the renal allograft. We have identified two HLA-A*0201-restricted nine-amino-acid cytotoxic T lymphocyte (CTL) epitopes of the BKV major capsid protein VP1, VP1(p44), and VP1(p108). Using tetramer staining assays, we showed that these epitopes were recogn...
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ژورنال
عنوان ژورنال: Annals of Translational Medicine
سال: 2020
ISSN: 2305-5839,2305-5847
DOI: 10.21037/atm.2020.01.15